A Thesis Submitted to the Faculty of Graduate Studies in Partial Fulfilment of the Requirements for the Degree of Master of Science Faculty of Kinesiology
نویسنده
چکیده
Proprioception describes our sense of self-position and movement without vision. It plays a key role in the production and control of movement. Affected in 50% of stroke patients, impairment in proprioception is correlated with poor motor recovery, functional outcomes, and extended hospitalization. Proprioception-targeted rehabilitation is lacking. To contribute to improved understanding of the anatomical regions underlying proprioception, this study aimed to identify brain areas responsible for impaired position sense post-stroke. Voxel-based lesion-symptom mapping compared lesion location and performance on quantitative robotic position sense assessment. This and region of interest analyses revealed that the hypothesized areas: the thalamus; posterior limb of the internal capsule; postcentral gyrus; posterior parietal association area were associated with poor position sense in addition to non-hypothesized areas: insula; lingual, inferior frontal, superior temporal, and middle temporal gyri. Position sense appears to be a multi-dimensional construct, processed via a distributed network of brain regions. iii Acknowledgements
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